Medical Diagnostics Literature References

IPS Literature References

Raman Spectroscopy - Medical Diagnostics

S.T. McCain, et al., “Multi-excitation Raman spectroscopy technique for fluorescence rejection,” Opt. Express, 16, 10975 (2008).

A.H. Chau, et al., “Fingerprint and high-wavenumber Raman spectroscopy in a human-swine coronary xenograft in vivo,” Journal of Biomedical Optics 13(4), 040501 (2008).

C.A. Lieber, et al,. “Comparison of Raman spectrograph throughput using two commercial systems: transmissive versus reflective.” Applied spectroscopy 62.5, 575 (2008).

Z.J. Smith and A.J. Berger, “Validation of an integrated Raman- and angular-scattering microscopy system on heterogeneous bead mixtures and single human immune cells,” Appl. Opt. 48, D109 (2009).

J. Bi, et al., “Raman spectroscopy for of bone quality in MMP-2 knockout mice”, Proc. SPIE 7166, Optics in Bone Biology and Diagnostics, 71660B (2009).

M.D. Keller, et al., “Spatially offset Raman spectroscopy of layered soft tissues.” Optics letters 34.7 926 (2009).

F.W.L. Esmonde-White, et al., “Exposed and transcutaneous measurement of musculoskeletal tissues using fiber optic coupled Raman spectroscopy,” Proceedings SPIE, 7548, Photonic Therapeutics and Diagnostics VI; 75484D (2010).

P.I. Okagbare, et al. “Development of non-invasive Raman spectroscopy for in vivo evaluation of bone graft osseointegration in a rat model.” Analyst 135, 3142 (2010).

F.W.L. Esmonde-White, et al., “Exposed and transcutaneous measurement of musculoskeletal tissues using fiber optic coupled Raman spectroscopy.” Photonic Therapeutics and Diagnostics VI. Vol. 7548. SPIE, (2010).

A. Khetani, et al., “Monitoring of heparin concentration in serum by Raman spectroscopy within hollow core photonic crystal fiber,” Optics Express, 19, 15245 (2011).

A. Khetani, et al., “Monitoring of adenosine within hollow core photonic crystal fiber by surface enhanced Raman scattering (SERS),” 2011 11th IEEE International Conference on Nanotechnology, 973 (2011).

X. Bi, et al., “Raman and mechanical properties correlate at whole bone- and tissue-levels in a genetic mouse model,” Journal of Biomechanics, 44, 297 (2011).

J.S. Nyman, et al., “Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone,” Journal of Bone and Mineral Research, 26, 1252 (2011).

B. Shim, et al., “An investigation of the effect of in vivo interferences on Raman glucose measurements”, Proc. SPIE 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III, 79060Z (2011).

P.I. Okagbare, et al., “Transcutaneous Raman spectroscopy for assessing progress of bone-graft incorporation in bone reconstruction and repair”, Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78834I (2011).

N. Stone, et al. “Surface enhanced spatially offset Raman spectroscopic (SESORS) imaging–the next dimension.” Chemical Science 2, 776 (2011).

X. Bi, et al., “Assessment of Breast Cancer Induced Bone Quality Changes Using Raman Spectroscopy,” in Biomedical Optics and 3-D Imaging, OSA Technical Digest (Optical Society of America, 2012), paper JM3A.43.

A.J. Makowski, et al., “In vivo analysis of laser preconditioning in incisional wound healing of wild-type and HSP70 knockout mice with Raman spectroscopy,” Lasers in Surgery and Medicine, 44, 233 (2012).

P.I. Okagbare and M.D. Morris, “Polymer-capped fiber-optic Raman probe for in-vivo non-invasive Raman tomography and spectroscopy”, Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82076J (2012).

M. Almond, et al., “Preclinical evaluation of a Raman spectroscopic probe for endoscopic classification of oesophageal pathologies”, Proc. SPIE 8219, Biomedical Vibrational Spectroscopy V: Advances in Research and Industry, 82190L (2012).

A.J. Makowski, et al., “Polarization control of Raman spectroscopy optimizes the assessment of bone tissue,” Journal of Biomedical Optics 18(5), 055005 (24 May 2013).

S. Yang, et al. “Laser wavelength dependence of background fluorescence in Raman spectroscopic analysis of synovial fluid from symptomatic joints.” Journal of Raman spectroscopy 44.8, 1089 (2013)

J.C.C. Day and N. Stone. “A subcutaneous Raman needle probe.” Applied spectroscopy 67, 349 (2013).

I.J. Pence, et al., “Assessing variability of in vivo tissue Raman spectra.” Applied Spectroscopy 67.7 789 (2013).

A.J. Makowski, et al., “Polarization in Raman spectroscopy helps explain bone brittleness in genetic mouse models,” Journal of Biomedical Optics 19(11), 117008 (2014).

A.J. Makowski et al. “The loss of activating transcription factor 4 (ATF4) reduces bone toughness and fracture toughness.” Bone 62 1-9 (2014).

M. Nitzan, et al., “Calibration-Free Pulse Oximetry Based on Two Wavelengths in the Infrared — A Preliminary Study,” Sensors, 14, 7420 (2014).

B. Li, et al., “A customized Raman system for point-of-care detection of arthropathic crystals in the synovial fluid.” Analyst 139.4 823 (2014).

C.M. O’Brien, et al.,”Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy”, Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032F (2015).

J. Desroches, et al., “Characterization of a Raman spectroscopy probe system for intraoperative brain tissue classification,” Biomed. Opt. Express 6, 2380-2397 (2015).

M.Z. Vardaki, et al. “Studying the distribution of deep Raman spectroscopy signals using liquid tissue phantoms with varying optical properties.” Analyst 140.15 5112 (2015).

S.L. Clauson, et al. “Detection of pesticides and metabolites using surface-enhanced Raman spectroscopy (SERS): Acephate.” Applied Spectroscopy 69.7, 785 (2015).

B. Gardner, et al., “Non-invasive chemically specific measurement of subsurface temperature in biological tissues using surface-enhanced spatially offset Raman spectroscopy,” Faraday Discuss., 187, 329 (2016).

K. St-Arnaud, et al., “Wide-field spontaneous Raman spectroscopy imaging system for biological tissue interrogation,” Opt. Lett. 41, 4692 (2016).

A. Creecy, A., et al. “Changes in the Fracture Resistance of Bone with the Progression of Type 2 Diabetes in the ZDSD Rat,” Calcif Tissue Int, 99, 289 (2016).

M.E. Oest, et al. “Parathyroid hormone attenuates radiation-induced increases in collagen crosslink ratio at periosteal surfaces of mouse tibia.” Bone 86, 91 (2016).

M.Z. Vardaki, et al., “Characterisation of signal enhancements achieved when utilizing a photon diode in deep Raman spectroscopy of tissue.” Biomedical optics express 7.6, 2130 (2016).

N.D. Israelsen, et al. “Rational design of Raman-labeled nanoparticles for a dual-modality, light scattering immunoassay on a polystyrene substrate.” Journal of biological engineering 10.1,1 (2016).

I. Pence and A. Mahadevan-Jansen. “Clinical instrumentation and applications of Raman spectroscopy.” Chemical Society Reviews 45.7, 1958 (2016).

S. Kim, et al, “Influence of water content on Raman spectroscopy characterization of skin sample,” Biomed. Opt. Express 8, 1130 (2017).

C.M. O’Brien, et al. “In vivo Raman spectral analysis of impaired cervical remodeling in a mouse model of delayed parturition,” Sci Rep 7, 6835 (2017).

J. Desroches, et al., “Raman spectroscopy in microsurgery: impact of operating microscope illumination sources on data quality and tissue classification,” Analyst, 142, 1185 (2017).

H. Ding, et al., “Effect of physiological factors on the biochemical properties of colon tissue – an in vivo Raman spectroscopy study,” Jl. of Raman Spectroscopy, 48, 902 (2017).

A.S. Moody, et al., “Surface Enhanced Spatially Offset Raman Spectroscopy Detection of Neurochemicals Through the Skull”, Anal. Chem. 89(11), 5688–5692 (2017)

S. Shibu, et al., “Small gold nanorods with tunable absorption for photothermal microscopy in cells,” Advanced Science, 4, 1600280 (2017).

A.J. Makowski, A., et al., “Applying Full Spectrum Analysis to a Raman Spectroscopic Assessment of Fracture Toughness of Human Cortical Bone,” Applied Spectroscopy, 71(10), 2385-2394, (2017)

H. Ding, et al. “In vivo analysis of mucosal lipids reveals histological disease activity in ulcerative colitis using endoscope-coupled Raman spectroscopy.” Biomedical Optics Express 8, 3426 (2017).

I.J. Pence, et al. “Clinical characterization of in vivo inflammatory bowel disease with Raman spectroscopy.” Biomedical optics express 8.2, 524 (2017).

S.M. Asiala, et al. “Surface-enhanced, spatially offset Raman spectroscopy (SESORS) in tissue analogues.” ACS applied materials & interfaces 9, 25488 (2017).

S.M. Lundsgaard-Nielsen, et al., “Critical-depth Raman spectroscopy enables home-use non-invasive glucose monitoring,” PLoS ONE 13(5), e0197134 (2018).

X. Jiang, et al., ”Surface-Enhanced Raman Nanoprobes with Embedded Standards for Quantitative Cholesterol Detection,” Small Methods,2, 1800182 (2018).

C.M. O’Brien, et al. “In vivo Raman spectroscopy for biochemical monitoring of the human cervix throughout pregnancy.” American journal of obstetrics and gynecology, 218, 528-e1 (2018).

J. Noonan, et al. “In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy.” Theranostics 8.22, 6195 (2018).

C. Shi, et al. “Bone morphogenetic protein signaling through ACVR1 and BMPR1A negatively regulates bone mass along with alterations in bone composition.” Journal of structural biology 201.3, 237 (2018).

M. Unal, et al.“Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone,” Sci Rep 9, 7195 (2019).

O.A. Okoh, et al., ”Synthesis and photophysical properties of meso-aminophenyl-substituted heptamethine dyes as potential leads to new contrast agents,” Coloration Technology, 135, 305 (2019).

E. Cannaday, et al., “Angularly resolved, finely sampled elastic scattering measurements of single cells: requirements for robust organelle size extractions,” Journal of Biomedical Optics 24(8), 086502 (2019).

D. Kotturi, et al., “Evaluating hydrogels for implantable probes using SERS”, Proc. SPIE 10894, Plasmonics in Biology and Medicine XVI, 108941B (2019).

S. Zhang, et al., “In vitro and in vivo datasets of topically applied ketorolac tromethamine in aqueous humor using Raman spectroscopy,” Data in Brief, 27, 104694 (2019).

G. Thomas, et al. “Innovative surgical guidance for label-free real-time parathyroid identification,” Surgery 165.1 114 (2019).

C.M. O’Brien, et al. “Development of a visually guided Raman spectroscopy probe for cervical assessment during pregnancy.” Journal of biophotonics, 12.2 e201800138 (2019).

Y.-C. Ou, et al. “Multimodal multiplexed immunoimaging with nanostars to detect multiple immunomarkers and monitor response to immunotherapies.” ACS nano 14.1, 651 (2019).

B. Gardner, et al., “Noninvasive simultaneous monitoring of pH and depth using surface-enhanced deep Raman spectroscopy, Jl. of Raman Spectroscopy, 51, 1078 (2020).

W.B. Sohn, et al., “Single-layer multiple-kernel-based convolutional neural network for biological Raman spectral analysis,” Jl. of Raman Spectroscopy, 51, 414 (2020).

S. Zhang, et al., “Dark-field illumination in conjunction with confocal Raman spectroscopy for real-time noninvasive aqueous humor investigation,” Optical Engineering 59(9), 092002 (2020).

Y. Yu., et al., “Confocal Raman micro-spectroscopy for evaluation of optical clearing efficiency of the skin ex vivo”, Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 112390W (2020).

J. Bec, et al., “Investigating Origins of FLIm Contrast in Atherosclerotic Lesions Using Combined FLIm-Raman Spectroscopy,” Frontiers in Cardiovascular Medicine, 7,122 (2020).

V.K. Bajpai, et al., “N,P-Doped Carbon Nanodots for Food-Matrix Decontamination, Anticancer Potential, and Cellular Bio-Imaging Applications,” Journal of Biomedical Nanotechnology, 16(3), 283 (2020).

G.S. Mandair, et al. “Radiation-induced changes to bone composition extend beyond periosteal bone.” Bone reports 12, 100262 (2020).

T. A. Shaik, et al. “FLIm-guided Raman imaging to study cross-linking and calcification of bovine pericardium.” Analytical chemistry 92.15, 10659 (2020).

T.A. Shaik, et al. “FLIm and Raman spectroscopy for investigating biochemical changes of bovine pericardium upon genipin cross-linking.” Molecules 25.17 3857 (2020).

M. Choi, et al., “Highly reliable SERS substrate based on plasmonic hybrid coupling between gold nanoislands and periodic nanopillar arrays,” Opt. Express 28, 3598 (2020).

K. M Fischenich, et al. “Human articular cartilage is orthotropic where microstructure, micromechanics, and chemistry vary with depth and split-line orientation.” Osteoarthritis and cartilage28.10 1362-1372 (2020).

G. Hiremath, et al. “Novel insights into tissue-specific biochemical alterations in pediatric eosinophilic esophagitis using raman spectroscopy.” Clinical and Translational Gastroenterology,11(7), e00195 (2020).

S. Zhang, et al. “Design and performance of a dark‐field probe with confocal Raman spectroscopy for ophthalmic applications.” Journal of Raman Spectroscopy52.7 1371-1375 (2021).

R. Vyumvuhore, et al. “Investigation of the molecular signature of greying hair shafts,” Int J Cosmet Sci, 43 332 (2021).

R.V. Chimenti, “Optics and photonics enable the fight against COVID-19,” Laser Focus World, Jan 2021.

D. Kotturi, et al., “Comparison of SERS pH probe responses after microencapsulation within hydrogel matrices,” J. of Biomedical Optics, 26(9), 097001 (2021).

P. Shitole, et al., “Influence of low dose naltrexone on Raman assisted bone quality, skeletal advanced glycation end-products and nano-mechanical properties in type 2 diabetic mice bone,” Materials Science and Engineering: C, 123, 112011 (2021).

J.B. Ford, et al., “Optimizing thermal block length during infrared neural inhibition to minimize temperature thresholds” Journal of Neural Engineering, 18(5), 056016 (2021).

M. Choi, et al., “Dual modal plasmonic substrates based on a convective self-assembly technique for enhancement in SERS and LSPR detection,” Opt. Express 29, 6179 (2021).

G. Throckmorton et al., Identifying optimal parameters for infrared neural stimulation in the peripheral nervous system,” Neurophotonics, 8(1), 015012-1 (2021).

I.J. Pence, et al. “Application driven assessment of probe designs for Raman spectroscopy.” Biomedical Optics Express 12.2, 852 (2021).

A.M. Fales, et al., “Evaluation of standardized performance test methods for biomedical Raman spectroscopy.” Journal of Biomedical Optics 27.7 074705 (2021).

E. Mannoh, et al. “Development of an imaging device for label‐free parathyroid gland identification and vascularity assessment.” Journal of Biophotonics 14.6, e202100008 (2021).

L.J. Moran, et al. “An experimental and numerical modelling investigation of the optical properties of Intralipid using deep Raman spectroscopy.” Analyst 146.24, 7601 (2021).

M. Plesia,, et al. “In Vivo Fiber Optic Raman Spectroscopy of Muscle in Preclinical Models of Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy.” ACS chemical neuroscience 12.10 1768 (2021).

J. J.P. Alix, et al. “The application of Raman spectroscopy to the diagnosis of mitochondrial muscle disease: A preliminary comparison between fibre optic probe and microscope formats.” Journal of Raman Spectroscopy 53.2 172 (2022).

D. Kapil, et al. “Machine Learning Assisted Handheld Confocal Raman Micro-Spectroscopy for Identification of Clinically Relevant Atopic Eczema Biomarkers.” Sensors 22.13, 4674 (2022).

Y. Liu, et al. “Fast and ultrafast thermal contrast amplification of gold nanoparticle-based immunoassays.” Scientific Reports 12.1, 1-8 (2022).

J. J.P. Alix, et al. “Rapid identification of human muscle disease with fibre optic Raman spectroscopy.” Analyst 147.11 2533-2540 (2022).

M.E. Berry., et al. “Tomographic Imaging and Localization of Nanoparticles in Tissue Using Surface-Enhanced Spatially Offset Raman Spectroscopy.” ACS Applied Materials & Interfaces (2022)

G.L. Monroy, et al. “Multimodal Handheld Probe for Characterizing Otitis Media—Integrating Raman Spectroscopy and Optical Coherence Tomography.” Frontiers in Photonics 3, 929574 (2022).

T. Ahn, et al. “Matrix/mineral ratio and domain size variation with bone tissue age: A photothermal infrared study.” Journal of Structural Biology 214.3 107878 (2022).

R. Ahmed, et al. “Sensitivity of the amide I band to matrix manipulation in bone: a Raman micro-spectroscopy and spatially offset Raman spectroscopy study.” Analyst148.19 4799-4809 (2023).

I. Kosik et al. “Preclinical evaluation of Raman spectroscopy for pedicular screw insertion surgical guidance in a porcine spine model.” Journal of Biomedical Optics28.5 057003-057003 (2023).

P. A. Pimiento, N. E. Dunn, and B. Sharma, “Surface-enhanced Raman spectroscopy combined with multivariate analysis for the detection and differentiation of dopamine and DOPAC in cerebrospinal,” J Raman Spectroscopy, 54(9), 917 (2023).

Y. Iritani, et al. “Heme Pocket Structure and Its Functional Implications in an Ancestral Globin Protein.” Biochemistry 62.18 2727-2737 (2023).

F. Daoust, et al. “A clinical Raman spectroscopy imaging system and safety requirements for in situ intraoperative tissue characterization.” Analyst 148.9 1991-2001 (2023).

R. Gautam, et al. “Assessment of spatially offset Raman spectroscopy to detect differences in bone matrix quality.” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy303 123240 (2023).

S. Quintero, et al. “A portable surface-enhanced Raman spectroscopy platform for biofluid analysis.” European Conference on Biomedical Optics. Optica Publishing Group, 2023.

S. Lee, et al. “Spatiotemporally controlled drug delivery via photothermally driven conformational change of self-integrated plasmonic hybrid nanogels.” Journal of Nanobiotechnology21.1, 191 (2023).

N.E. Dunn, “Integration of Raman Spectroscopy and Python-based Data Analysis for Advancing Neurobiological Research”, Univ. of Tenn. PhD Thesis (2023).

Chi Shu, Li Gong, and Zhiwei Huang, “Bessel Beam Beating-Based Spontaneous Raman Tomography Enables High-Contrast Deep Tissue Raman Measurements,” ACS Photonics, 11 (5), 2022-2034 (2024).

J.D. Muñoz-Bolaños, et al. “Design of a Dispersive 1064 nm Fiber Probe Raman Imaging Spectrometer and Its Application to Human Bladder Resectates.” Applied Sciences 14(11) 4726, (2024).

M.J.E. Domingo, et al. “Biomechanical and Compositional Changes in the Murine Uterus with Age.” bioRxiv 2024-09. (2024).

S. Quintero, et al. “Portable Raman platform for SERS droplets microfludics.” 2024 International Conference on Optical MEMS and Nanophotonics (OMN). IEEE, (2024).

F. Nicolson, et al. “In vivo imaging using surface enhanced spatially offset raman spectroscopy (SESORS): balancing sampling frequency to improve overall image acquisition.” npj Imaging2.1 7 (2024).

D. Kim, et al. “Multimodal Golden DNA Superstructures (GDSs) for Highly Efficient Photothermal Immunotherapy.” ACS nano18.2 1744-1755 (2024).

E. Zamani, et al. “Spectral effects and enhancement quantification in healthy human saliva with surface‐enhanced Raman spectroscopy using silver nanopillar substrates.” Lasers in Surgery and Medicine56.2 206-217 (2024).

B. Gardner, “Guided principal component analysis (GPCA): a simple method for improving detection of a known analyte.” Analyst149.1 205-211 (2024).

E. Stepula, et al. “Label-free 3D molecular imaging of living tissues using Raman spectral projection tomography.” Nature Communications15.1 7717 (2024).

J. Wu, et al. “Synovial fluid research based on SERS and SERRS for enhanced detection of biomarkers in staged osteoarthritis.” Journal of Biophotonics, e202400024 (2024).

K. Ember, et al. “Liquid saliva-based Raman spectroscopy device with on-board machine learning detects COVID-19 infection in real-time.” Analyst149.22 5535-5545 (2024).

A.S. Rourke-Funderburg, et al. “Characterizing Variability in Non-Invasive Hydration Monitoring Using Raman Spectroscopy.” Applied Spectroscopy 00037028241307043 (2024).

R. Sentosa, et al. “Development of a label-free, functional, molecular and structural imaging system combining optical coherence tomography and Raman spectroscopy for in vivo measurement of rat retina.” Biomedical Optics Express16.2 566-577 (2025).

C.S. Bastías, et al. “Pregnancy and age differentially affect stiffness, injury susceptibility, and composition of murine uterosacral ligaments.” Journal of the Mechanical Behavior of Biomedical Materials 163 106874 (2025).

R. Hua, et al. “Pivotal roles of biglycan and decorin in regulating bone mass, water retention, and bone toughness.” Bone Research 13.1 2 (2025).

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IPS Literature References

Raman Spectroscopy - Medical Diagnostics

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